The Effect of Thermoplastic Zein And Hydroxyapatite on the in vitro Degradation and Biological Response of Novel Multi-Phase PCL Scaffolds for Bone Tissue Engineering
نویسندگان
چکیده
Galway, Ireland The Effect of Thermoplastic Zein And Hydroxyapatite on the in vitro Degradation and Biological Response of Novel Multi-Phase PCL Scaffolds for Bone Tissue Engineering Aurelio Salerno, Stefania Zeppetelli, Ernesto Di Maio, Salvatore Iannace, Paolo A. Netti Corresponding Author: [email protected] 1 Interdisciplinary Research Centre on Biomaterials and Italian Institute of Technology, Naples, Italy; 2 Institute of Composite and Biomedical Materials, National Research Council, Naples, Italy and 3 Department of Materials and Production Engineering, University of Naples Federico II, Naples, Italy
منابع مشابه
Aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineering
Aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (PCL), poly (vinyl alcohol) (PVA) and hydroxyapatite nanoparticles (nHA). The morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. Scanning electron microscopy revealed fibers with an average diameter of 123 ± 3...
متن کاملPreparation and characterization of PCL polymeric scaffolds coated with chitosan/ bioactive glass/gelatin nanoparticles using the tips methodology for bone tissue engineering
Objective(s): The present study aimed to prepare polycaprolactone (PCL) scaffolds with high porosity and pore interconnectivity, in order to copy the microstructure of natural bones using the thermally induced phase separation (TIPS) technique. Materials and Methods: The scaffolds were coated with chitosan (CH), bioactive glass (BG), and gelatin nanoparticles (GEL NPs) and assessed using ...
متن کاملElectrospun biocompatible Gelatin-Chitosan/Polycaprolactone/Hydroxyapatite nanocomposite scaffold for bone tissue engineering
In recent years, nanocomposite scaffolds made of bioactive polymers have found multiple applications in bone tissue engineering. In this study composite nanofibrous structure of gelatin (Gel)/chitosan (Cs)-polycaprolactone (PCL) containing hydroxyapatite (HA) were fabricated using co-electrospinning process. To assay the biocompatibility and bioactivity of electrospun nanocomposite scaffolds, t...
متن کاملElectrospun biocompatible Gelatin-Chitosan/Polycaprolactone/Hydroxyapatite nanocomposite scaffold for bone tissue engineering
In recent years, nanocomposite scaffolds made of bioactive polymers have found multiple applications in bone tissue engineering. In this study composite nanofibrous structure of gelatin (Gel)/chitosan (Cs)-polycaprolactone (PCL) containing hydroxyapatite (HA) were fabricated using co-electrospinning process. To assay the biocompatibility and bioactivity of electrospun nanocomposite scaffolds, t...
متن کاملIn vitro and In vivo Investigation of poly(lactic acid)/hydroxyapatite nanoparticle scaffold containing nandrolone decanoate for the regeneration of critical-sized bone defects
Objective(s): Bone tissue engineering is aimed at the fabrication of bone graft to ameliorate bone defects without using autografts or allografts. Materials and Methods: In the present study, the coprecipitation method was used to prepare hydroxyapatite (HA) nanoparticles containing nandrolone. To do so, 12.5, 25, and 50 mg of nandrolone were loaded into poly(lactic acid) (PLA)/nano-HA, a...
متن کامل